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Maskless photochemical micropatterning

Martynas Gavutis — Tue, 04 Apr 2023 07:39:31 +0000

We have developed a straightforward method for creating large-area, microscale resolution patterns of functional amines on self-assembled monolayers. The technique utilizes flat elastomeric stamp enriched with photoacid and HD-DVD optical pickup to locally deprotect the N-Boc groups and form chemical patterns with resolution below 10µm. Further details can be found in the article published in ACS Applied Materials and Interfaces: https://pubs.acs.org/doi/10.1021/acsami.2c20568 .

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Laser formed gratings generate hybrid plasmonic modes

Martynas Gavutis — Mon, 03 Apr 2023 18:52:45 +0000

We have employed direct laser writing technique to fabricated large-scale (5 × 5 mm²) gold gratings which generate hybrid lattice plasmon polaritons in the Vis-NIR range. The key element of each grating is a hollow gold microbump that is formed by exposing a thin gold coating with a tightly focused laser beam. The formed gratings can be used in microscopy, surface-enhanced Raman spectroscopy, or in the development of plasmonic nanolasers. Further details can be found in the article published in Advanced Optical Materials: https://onlinelibrary.wiley.com/doi/10.1002/adom.202100027 .

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A reliable substrate for biochip fabrication

Martynas Gavutis — Tue, 25 Oct 2022 13:16:50 +0000

Recently, we have introduced an efficient protocol for UV-controlled photochemical synthesis of stable PEG hydrogel coatings on glass substrates. They proved advantageous for fabrication of protein patterns, especially as cell-adhesive microfeatures for single-cell analysis, as well as for spatially controlled culture. We have demonstrated that the hydrogel-based architectures on glass are non-toxic, and they show no indications of disintegration/chemical degradation even under prolonged cell culture conditions. Our platform is highly promising in the design of protein and cell arrays, microfluidic devices, tissue/organ-on-a-chip. Please see the references below for more details and first application examples.

References:
https://pubs.acs.org/doi/abs/10.1021/acsami.0c04085 ;
https://www.mdpi.com/1422-0067/22/23/12702 ;
https://www.mdpi.com/2079-6412/12/7/880 ;

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AFM imaging of large areas gets faster

Mindaugas — Thu, 09 Mar 2017 08:36:32 +0000

Baltfab researchers have developed an atomic force microscopy (AFM) scanning technique which enables AFM imaging of large areas at unprecedented (up to 45 mm/s) scanning speed. More information and the link to the paper can be found here: https://doi.org/10.1021/acsami.9b07547

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New process for lipid nanopatterning

Mindaugas — Sun, 14 Feb 2016 19:41:57 +0000

BALTFAB scientists have published a paper on scanning probe-based printing of nanoscopic lipid phases. The process is based on fast transfer (up to 100 µm/s) of lipids, including those bearing functional groups, from the probe onto substrates with controlled hydrophilicity. The process allows obtaining lipid assemblies ranging from sub-monolayers to multi-lamellar stacks, with controlled lateral dimensions from 100 nm up to tens of micrometers. Such a process can be useful in developing cell membrane in vitro models as well as for biosensing and pharmaceutical applications.

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