A reliable substrate for biochip fabrication

Recently, we have introduced an efficient protocol for UV-controlled photochemical synthesis of stable PEG hydrogel coatings on glass substrates. They proved advantageous for fabrication of protein patterns, especially as cell-adhesive microfeatures for single-cell analysis, as well as for spatially controlled culture. We have demonstrated that the hydrogel-based architectures on glass are non-toxic, and they show no indications of disintegration/chemical degradation even under prolonged cell culture conditions. Our platform is highly promising in the design of protein and cell arrays, microfluidic devices, tissue/organ-on-a-chip. Please see the references below for more details and first application examples.

https://pubs.acs.org/doi/abs/10.1021/acsami.0c04085 ;
https://www.mdpi.com/1422-0067/22/23/12702 ;
https://www.mdpi.com/2079-6412/12/7/880 ;

Baltfab_PEGMA hydrogel

Martynas Gavutis
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